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She is a member of the Zeta Rho Pi sorority at California University in which Naomi Clark joins after getting denied entry at the Kappa sorority by Holly Strickler. She is overweight, but has a friendly attitude and likes that Naomi smells like lavender ice cream.
She is with the sorority when they are tricked into wearing togas at a big mixer, but Naomi turns things around by making a grand entrance. She later leaves after Naomi is revealed to have called them losers.
However, Margene is all about sisterhood and forgiveness, stating that she forgives Naomi and wants to back her up in getting revenge on Holly.