Zuckerman was born and raised in the town of Los Altos, California, where he attended Bullis-Purisima Elementary School. He moved to Los Angeles to pursue an acting career after finishing the seventh grade at Egan Junior High School, where he had been elected student body president. He also attended The Buckley School in Sherman Oaks, California and as of 2003 was attending Princeton University where he was a member of the Delta Kappa Epsilon Fraternity.
He played Eddie Orlofsky, "the Fairview strangler" on the hit dramedy Desperate Housewives. Zuckerman has a recurring role in the CW series 90210 as Naomi's love interest, Max Miller.
- He shares the same birthday as Matt Lanter but is two years younger.