- „Andrea, you are a remarkable person. You really are”
Brandon and Andrea meet at The Blaze, which becomes the scene of many heated debates between the two of moral issues concerning the paper, always underpinned by their mutual, undeniable attraction which neither ever find the right time to truly act on. While Andrea is first considered a social outcast and Brandon quickly befriends 'in-crowd' people such as rich boy Steve Sanders and revered, rich loner Dylan McKay, the focus early on is how Andrea has an obvious crush on Brandon, but it goes both ways.
Brandon is the first to spontaneously kiss Andrea and both are incredibly jealous of their respective significant others. The pairing seems to be bandied about quite a bit, with a bunch of near-misses in them finally getting together. It is not stated, but one can speculate that the two never did get together due to the necessity of the pregnancy storyline, and possibly Carteris's departure from the show a year later.
Andrea and Brandon first meet when Brandon seeks out a place on the West Beverly Blaze and encounters Andrea – the intense, dismissive editor-in-chief. Brandon's persistence and well-intentioned demeanor picks apart Andrea's defenses and she agrees to let him work on the Blaze. When Brandon discovers Andrea living out of district, the two start a friendship as Andrea allows herself for the very first time, to put faith and stock in a peer from her high school, which is more or less a job to her. This begins a transformation in Andrea, as she starts opening up a bit to people and develop friendships at West Beverly.
Brandon and Andrea's friendship is intense from the very beginning, and only grows. Andrea becomes angry with Brandon during his fling with Marianne Moore, which could come off as jealousy – except it's hugely informed by Andrea's lack of friendships and vulnerability to others at West Beverly. As she says to him, she thought he was different. She has a similar reaction when Brandon considers cheating on a test, prompting his equally impassioned response to her that he feels she's so invested in his morality, like they're in a relationship.
While Andrea is aware of her growing feelings for Brandon, he is somewhat ignorant to his, but often expresses them when he's emotionally vulnerable. When Brenda decides to throw a party, with their parents away for the weekend, Brandon invites Andrea, gets tipsy and promptly kisses her, leaving Andrea mortified as she feels it's insincere, and Brandon's beer-fueled reaction to her rejection is heavy remorse, indicating that this was him daring to express his true feelings.
They continue to work together and be close, Andrea jealous of the girls Brandon dates. Once the Spring Dance comes around, Brenda assumes Brandon will ask Andrea, but before she can hint at anything he says he's not going. Kelly then asks Brandon, although Brandon's not interested in her. When Andrea decides to show up anyway, Brandon (who continually remarks that he hates dancing) asks Andrea to dance and they slow dance.
Once Brandon learns he and his family are moving back to Minnesota, Andrea decides to act on their feelings and suggest they sleep together.
- „We may never see each other again”
- —Andrea to Brandon[src]
Brandon says yes and they plan to meet up at The Peach Pit after closing. Andrea's nervous and asks Kelly for advice. Every kiss that they share is passionate and completely overwhelms both of them, implying (as well as their constant bickering) that they would experience great passion as a couple. Their plans are thwarted by a goodbye party for the Walsh family, arranged by Kelly (suspiciously also the only person who knew when and where Brandon and Andrea were meeting up).
On the last day of school, Andrea serves cake at the paper and after everyone leaves, Brandon tries to talk to her about their thwarted plans. Where Brandon seems open to the idea of starting to date, Andrea desists, saying she thinks they should be friends, which Brandon accepts. Even though this was her decision, Andrea has a hard time coming down to the beach club and commiserates with Brenda, who doesn't want to face Dylan. The experience strengthens their bond and Andrea feels okay asking Brandon to be a big brother to a kid, who they work together to help when it turns out he's being hit by his mother. When the gang go camping at Yosemite and Brandon has a near-death experience, his reaction afterwards is to take Andrea aside and give her a huge hug. Andrea briefly dates her drama teacher before summer ends, which Brandon doesn't seem to learn about.
When they return to West Beverly for their junior year, Andrea doesn't change her mind about dating Brandon, but still gets jealous of Brandon's romances with Emily, Tricia and Marcie. Brandon seems to have moved on after Andrea said she wanted to be friends, but is still aware of her jealousy. He never calls her on it, but also doesn't say that he's moved past the possibility of them as a couple, nor indicates that he has no romantic feelings for her. Andrea is short with the girls Brandon dates and always seems relieved when they don't stick around, but continues to be his friend too.
They hit some bumps in their junior year; once when Brandon unwittingly gets high on U4EA and his reaction to seeing Andrea is to start making out with her in front of both Emily and Steve, even though he's with Emily at the time. While Steve had encouraged Andrea to express her feelings for Brandon, she doesn't after being shocked by his behaviour and subsequently when he breaks up with Emily. Another conflict arises when Brandon insults Andrea by calling her a hypocrite to be advocating for condoms in the school when she's never had sex. After getting some much needed guidance from his sister, Brandon apologises to Andrea, who's mortified to have had a guy she has feelings for say something like that to her.
- Andrea – Brandon, do you think I'm a geek for coming to this dance by myself?
- Brandon – No not at all. We never get to slow dance in the newsroom
- ―Cutie pies[src]
- „You never seize to amaze me”
- —Brandon to Andrea[src]
- „There's nowhere else I'd rather be right now and no one else I'd rather be with”
- —Brandon to Andrea[src]
- „Brandon and Andrea have been talking about being on Jeopardy since they were in high school”
- —Cindy to a bemused Kelly[src]